physical chemical principles in the pharmaceutical sciences. / Patrick J. Sinko. Rev. ed. of: Physical pharmacy / Alfred Martin. Martin's physical pharmacy and pharmaceutical sciences . Physical Pharmacy, upon its publi- scientific excellence as applied to Technol. 11, 3–28, Sixth Edition. Copyright cO , Lippincott Williams & Wilkins, a Wolters Kluwer business. Martin's physical pharmacy and pharmaceutical sciences: physical chemical and Physical Pharmacy was for Professor Martin truly a labor of.
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Request PDF on ResearchGate | Martin's physical pharmacy and , Lippincott Williams & Wilkins, a Wolters Kluwer business. Request PDF on ResearchGate | Martin's physical pharmacy and for the force of gravity and no precipitation during storage a few days (Martin et al., ;. Martin's Physical Pharmacy and Pharmaceutical Science 5th Ed. - Free ebook download as PDF File .pdf) or read book online for free. Pharmacy Books.
The solubility of satranidazole in various dioxane-water mixtures was analyzed in terms of solute-solvent interactions using a modified version of Hildebrand-Scatchard treatment for regular solutions.
The solubility of satranidazole in the binary solvent, dioxane-water shows a bell-shaped profile with a solubility maximum well above the ideal solubility of the drug.
The new approach provides an accurate prediction of solubility once the interaction energy is obtained. A quartic expression of W in terms of solvent solubility parameter was found for predicting the solubility of satranidazole in dioxane-water mixtures.
The method has potential usefulness in preformulation and formulation studies during which solubility prediction is important for drug design. Keywords: Dioxane, extended Hildebrand solubility approach, ideal solubility, interaction energy, regular solution theory, satranidazole, solubility parameter Solubility data on drugs and pharmaceutical adjuncts in mixed solvents have wide applications in the drug sciences.
Knowledge of interaction forces between solutes and solvents are of considerable theoretical and practical interest throughout the physical and biological sciences[ 1 ].
The theory of solution is one of the most challenging branch of physical chemistry. The Hildebrand-Scatchard theory of regular solution is the pioneer approach in this field, used to estimate solubility only for relatively non-polar drugs in non-polar solvents[ 2 ].
An irregular solution is one in which self-association of solute or solvent, solvation of the solute by the solvent molecules, or complexation of two or more solute species are involved[ 3 ].
Polar systems exhibit irregular solution behaviour and are commonly encountered in pharmacy. The extended Hildebrand solubility approach EHSA , a modification of the Hildebrand-Scatchard equation, permits calculation of the solubility of polar and non polar solutes in solvents ranging from non polar hydrocarbons to highly polar solvents such as water, ethanol, and glycols[ 4 ].
Written in English. Table of Contents Basic principles States of matter Thermodynamics Determination of the physical properties of molecules Equilibrium phenomena Nonelectrolytes Solutions of electrolytes Ionic equilibria Electromotive force and oxidation-reduction Buffered and isotonic solutions Solubility and distribution phenomena Complexation and protein binding Mass transport in pharmaceutical systems I: Edition Notes Includes bibliographical references and index.
Other Titles Physical pharmacy pharmaceutical sciences. M34 The Physical Object Pagination p. Check nearby libraries with: WorldCat Library.
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April 16, Edited by bgimpertBot. April 14, Edited by Open Library Bot.When the Queen packs off Princess Smartypants to finishing school, it seems that our favourite royal might become a perfect princess after all History Created April 1, 8 revisions Download catalog record: October 9, Every small business needs to punch above its weight online.
Martin's physical pharmacy pharmaceutical sciences Patrick J.